Stanford Lab Open-Sources SMFNet, a Discrete Diffusion Model for Single-Molecule Footprinting
anshulkundaje · x · 2026-11-06
Anshul Kundaje 实验室发布 SMFNet 的官方开源实现（GitHub，MIT 协议）：一个离散扩散模型，以 DNA 序列为输入（2048bp），生成中心 1024bp 区域的单分子足迹（SMF）读段分布，每个读段逐位点标注分子被保护或可及。采样大量读段可呈现序列编码的分子状态范围而非仅平均可及性。模型支持三种实验类型训练，包括 Nanopore SMF（CpG/GpC 甲基酶）等。
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