Baker Lab designs de novo transcriptional regulators that recruit specific cofactors
AllThingsApx · x · 2026-10-22
A new Baker Lab paper takes a bottom-up approach to designing transcriptional regulators:
- Instead of relying on natural activation domains, the team designed compact proteins that recruit specific cofactors
- Activators are done; repressors are next
A step from protein structure design toward controlling gene regulation, with implications for synthetic biology and gene therapy.
Related event: Baker Lab Designs De Novo Transcriptional Activators(3 posts)→
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