Baker Lab Designs De Novo Transcriptional Activators

Baker Lab's new paper describes a bottom-up approach that designs compact, high-affinity proteins to recruit specific cofactors, overcoming the weak-interaction limitation of natural activation domains and enabling precise transcriptional regulation.

2026-10-22 ~ 2026-10-23 · 3 related posts

• Baker lab designs transcriptional regulators from scratch, recruiting cofactors without natural activation domains — AllThingsApx · 2026-10-22
• Baker Lab designs de novo transcriptional regulators that recruit specific cofactors — AllThingsApx · 2026-10-22
• DL-designed proteins recruit coactivators with nanomolar affinity for precise transcriptional control — KevinKaichuang · 2026-10-23