Self-Amplifying RNA Programs Stem Cell Fate in One Transfection, Cell Reports Methods Paper Shows
anshulkundaje · x · 2026-10-22
MIT's Galloway Lab published a Cell Reports Methods paper showing self-amplifying RNA can program hiPSC fate and enable functional biosensing for over a month with a single transfection, without genomic integration — including neuronal differentiation, voltage/calcium reporter delivery, and extended imaging in 3D cardiac spheroids.
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