Leash Bio: AI Agents Run 10,000 Drug-Discovery Campaigns in a Weekend
niloofar_mire · x · 2026-10-15
Latent Space podcast: wet lab to RL environment
An interview with Leash Bio covering AI drug discovery:
- DNA-encoded libraries (DEL) generate billions of protein–molecule measurements for training data.
- In Leash's Kaggle competition, no team beat chance on an unseen chemical library, exposing extrapolation limits.
- Public datasets can teach AI to recognize the chemist instead of understand chemistry; engineered protein mutations reveal model memorization.
- Replayable experimental worlds let agents run 10,000+ medicinal chemistry campaigns in a weekend.
- Also: Hermes vs. Boltz, DEL hits to mouse studies in six months, and how scaling's Bitter Lesson could unlock the next generation.
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