AI-designed proteases can be tuned to cut specific disease-linked proteins

Ars Technica AI · rss · 2026-10-15

Researchers used AI protein-design tools to keep the catalytic cores of two protease types and replace the rest of the protein, creating tunable enzymes that can cut specific proteins in half — demonstrated on proteins linked to neurological diseases — effectively short-circuiting evolution's protease diversification for targeted therapeutics.

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