DeepMind releases AlphaGenome 2, predicting DNA variant effects across hundreds of cell types
osanseviero · x · 2026-11-12
Google DeepMind announced AlphaGenome 2, its next-generation DNA sequence model, available today via the AlphaGenome API.
- Predicts how DNA sequences and their variants affect specific human cell types, zooming in from tissue-level averages to individual cell states to pinpoint cellular drivers of disease.
- Trained on 100M+ cell profiles, positioned as a predictive engine of human genetics.
- Redesigned architecture delivers a step-change in variant prediction performance, capturing disease-relevant effects missed by broad-tissue models.
- Builds on AlphaGenome Atlas, which already covers predictions for all 9 billion possible single-letter changes in the human genome.
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