Investors debate: should biomedical AI capital pool into LLMs or a plurality of ideas

dr1337 · x · 2026-11-08

A debate over whether capital should concentrate on LLM-driven biomedical moonshots or a plurality of approaches.

Investor @dawallach says he's rooting for the LLM thesis and accelerating it, but must assign probabilities to highly uncertain scenarios where timing is hardest. With limited money and people, going all-in on moonshots would sacrifice lower-risk near-term wins with immediate patient impact; he thinks the market's current ratio is roughly right, perhaps slightly underweight on moonshots.

@dr1337 agrees: it's not a foregone conclusion that scaling LLMs solves all biomedical problems, and capital is zero-sum — money pooling into the same ideas is money not funding a plurality of possible outcomes.

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