BioSimBench launches: frontier models partially fail at predicting real cell responses; a 27B RL-trained model beats them

divy93t · x · 2026-11-05

BioSimBench launches to test whether AI can simulate biology: predicting how real cells respond to drugs, gene knockdowns, and immune signals. Frontier models only get part of it right, while a 27B model trained in the team's RL environment BioSimGym outscores the best of them on every task. Google's Thomas Divé invited the author to benchmark the latest Gemini models, setting up a concrete test of whether specialized small models can beat frontier generalists in AI-for-science.

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