Prompting Evo 2 with 14 examples: 15% of generations pass lanmodulin filters

garykbrixi · x · 2026-10-29

Lanmodulins bind rare-earth metals and have been revolutionary for mining, yet their family has only 14 examples. Prompted with these, up to 15% of Evo 2 generations pass HMM, novelty and diversity filters, with more samples yielding progressively more novel designs. The same holds for rubisco and highly diverse families like anti-CRISPRs, where prompt diversity trades yield against novelty.

Related event: Evo 2 exhibits emergent in-context learning, enabling few-shot genomic design(14 posts)→

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