Open-sourced Carbon-X DNA model exposes frontier LLM refusals: Opus 5.5 drops 17.7% to 1.1% on genomics
LoubnaBenAllal1 · x · 2026-10-22
The Carbon-X DNA model has been released openly so anyone can study its capabilities and limits, advancing open science in AI for Biology.
The author highlights a striking issue: frontier models often refuse routine genomics requests, hindering legitimate research. On next-base prediction, Opus 5.5 falls from 17.7% at low reasoning effort to 1.1% at max as refusals climb, with Gemini 4 Argon showing the same pattern.
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