RNA fingerprinting method published in Cell infers drivers of cellular responses from Perturb-seq
anshulkundaje · x · 2026-10-10
The satijalab team, together with David Knowles, published RNA fingerprinting in Cell.
- The approach uses Perturb-seq experiments—where the causal perturbation is known—to learn what drives cellular responses in new, unseen datasets.
- By treating perturbation experiments as supervised signal, the method can transfer to large-scale single-cell data where direct perturbations aren't feasible, with implications for gene regulation and disease studies.
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