Biodistribution Hinges on Binding ~1-2k Surface Receptors, a Hidden Challenge for AI Drug Design
anshulkundaje · x · 2026-10-01
Part 6 of a thread: a binder's biodistribution and unintended agonism depend on its propensity to bind any of the 1,000-2,000 surface-accessible receptors in the body—making off-target effects a hard-to-predict challenge for AI drug design.
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