Four 'unlikely' mutations boost designed protease Dokki-15 turnover 58x
AllThingsApx · x · 2026-09-26
Follow-up data on the Baker lab's cysteine protease design work: four mutations rated unlikely by ProteinMPNN boosted Dokki-15's turnover 58x (0.0011 to 0.064 s⁻¹). Apparent KM rose from 89 to 154 µM, though the author notes it doesn't directly measure binding affinity.
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