Open-source effort designs personalized pancreatic cancer vaccine for 34-year-old patient
jajoosam · x · 2026-11-11
RNA Foundry and PopVax are openly developing a personalized cancer vaccine for Yashdeep Bindal, a 34-year-old with stage IV pancreatic cancer, with his consent. After a rare CDH1::NRG1 fusion was identified, he was switched to zenocutuzumab with a strong initial response. The team has released his tumor sequencing data and vaccine design, inviting external experts in antigen discovery and immunotherapy to review and contribute before manufacturing at the RNA Foundry. Their first mRNA-LNP vaccine (infectious disease) entered a phase 1 trial in Australia earlier this year; its design will be open-sourced once the trial concludes.
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