Federated fine-tuning of OpenFold3 by five pharma companies lifts interface predictions from 35.6% to 52.1% on private structures
AllThingsApx · x · 2026-09-14
Apheris reports a first for federated drug discovery: five pharmaceutical companies fine-tuned OpenFold3 Preview 2 across 20,167 private structures, none of which left their local environments.
- High-quality interface predictions rose from 35.6% to 52.1% on 1,056 held-out structures
- Correct ligand poses improved from 28.9% to 46.8%, ahead of every public model
Caveat: neither the participating companies' structures nor the fine-tuned model weights (AISB-1-Fed) are publicly available.
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