AI-engineered CAR binders completely cleared tumors in vivo where FDA-approved binders failed
anshulkundaje · x · 2026-09-10
Caleb Lareau's team shared key data from their AI-engineered CAR research: after a round of helpful peer review, they tested their CARs in a challenging in vivo tumor model. While the binders used on FDA-approved CARs failed to control the tumor, their AI-designed binders completely cleared it.
A rare positive in vivo validation for AI protein design in cancer therapy—outperforming clinically approved molecules under a tougher model introduced during review.
Related event: MSK's AI-Designed Anti-Cancer Proteins Fully Clear Tumors in Mice(3 posts)→
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