Nature Methods comment: TCR antigen specificity data limited by quality, not quantity
victorgreiff · x · 2026-09-09
A Nature Methods Comment by Shugay et al. argues that TCR–antigen specificity data are limited by quality, not quantity.
- High-throughput methods and databases have massively expanded TCR specificity data, but much of it is noisy or weakly validated
- The authors lay out the field's bottlenecks and proposed fixes: rigorous experimental validation, statistical filtering, and multimodal AI approaches to derive high-confidence records
A positioning piece on why data governance plus multimodal modeling, not more raw data, will unlock reliable TCR specificity prediction.
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