Paper: miRNAs modulate bioelectrical regionalization in multicellular aggregates
drmichaellevin · x · 2026-08-16
This study theoretically explores how microRNAs (miRNAs) modulate ion channel protein expression and cell membrane potentials in multicellular aggregates. The authors simulate spatiotemporal regionalizations of bioelectrical states using a biophysical model that captures the interplay between genetics and bioelectricity at the single-cell level. The research demonstrates how intercellular connectivity establishes coupled bioelectrical and transcriptional state patterns at the multicellular level.
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