ArchVelo models single-cell trajectories from paired ATAC-seq and RNA-seq data
anshulkundaje · x · 2026-07-28
ArchVelo is a new framework for inferring cellular trajectories from paired single-cell ATAC-seq and RNA-seq data.
The method models chromatin accessibility as shared archetypes that influence transcription over time. According to the paper, it improves trajectory inference accuracy and latent-time alignment at the gene level, while also decomposing trajectories into archetypal components and surfacing underlying transcriptional programs.
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