Open-Source Model Powers Structural Biology Agent Demo
MaziyarPanahi · x · 2026-07-11
This post demonstrates a fully open-source structural biology agent workflow:
- Brain: GLM-5.2
- Vision: Qwen3-VL running via Llama.cpp
- Interface/Rendering: Open-source Mol viewer
- Orchestration: Pydantic AI
- Target: EGFR + erlotinib structure from RCSB PDB
The author mentions that the entire process used just a single prompt to generate 6 render versions. At each step, the vision model provides actual critiques, iterating until the drug's position in the pocket "looks more reasonable." Follow-up replies emphasize that this is a demonstration of open models capable of "doing structural biology on their own."
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