Largest Protein Fitness Dataset Exposes ML Model Limits
The largest experimental dataset of its kind, covering 13,000 measurements across three proteins, reveals highly rugged fitness landscapes with many functional sequences between orthologs, and shows current ML models cannot reliably distinguish functional from non-functional sequences.
2026-09-01 ~ 2026-09-01 · 2 related posts
- Study: Current ML models fail to distinguish functional protein sequences — KevinKaichuang · 2026-09-01
- Large Dataset Shows Protein Fitness Landscapes are Rugged — KevinKaichuang · 2026-09-01