Large Dataset Shows Protein Fitness Landscapes are Rugged
KevinKaichuang · x · 2026-09-01
The largest experimental protein sequence-fitness dataset, with 13k measurements across 3 proteins, reveals that fitness landscapes are rugged. It shows many functional sequences exist between orthologs, and current ML models fail to distinguish functional from non-functional sequences.
Related event: Largest Protein Fitness Dataset Exposes ML Model Limits(2 posts)→
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