Yamanaka lab preprint: partial reprogramming outcomes diverge sharply by cell lineage
MaxUnfried · x · 2026-11-14
A new preprint from Shinya Yamanaka's lab at the Gladstone Institutes uses reversible, traceable Sendai-OSKM to test whether partial reprogramming makes human cells biologically younger while recovering identity and function. Outcomes diverged by lineage:
- Endothelial cells: recovered identity, retained younger DNA methylation age, improved vascular function.
- Cytotoxic T cells: recovered only after shallow reprogramming, with enhanced effector function.
- Fibroblasts: stayed methylation-younger but never fully regained proliferative capacity.
The study, "Partial reprogramming reveals lineage-specific uncoupling of rejuvenation, function, and recoverability in human cells," concludes rejuvenation, function, and recoverability are uncoupled across lineages—so therapies must be optimized per lineage. Commenter Max Unfried notes this is unlikely to extend lifespan much or deliver true cellular rejuvenation.
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