Blank Bio unveils Ladon, an RNA foundation model predicting patient outcomes

anshulkundaje · x · 2026-11-13

Blank Bio's team introduced Ladon, a transcriptomic foundation model built for clinical use that predicts disease trajectory and treatment response — including progression-free survival — addressing patient heterogeneity where identical diagnoses and treatments lead to divergent outcomes. Key details: joint training on bulk RNA and single-cell sequencing data; validation of response prediction on held-out clinical trials; discovery of robust predictive biomarkers from external data; and technical work on cell-type deconvolution, joint expression/isoform sequence modeling, and tissue-aware isoform prediction. Positioned as a first step toward learning more from every enrolled patient and unlocking clinical trial abundance.

Original post →

Blank Bio unveils Ladon, an RNA foundation model predicting patient outcomes

More from Apps