CAR-T brings lupus patients to full remission; randomized trials now underway
NikoMcCarty · x · 2026-11-13
Niko McCarty reviews the rapid rise of CAR-T therapy for autoimmune disease: a 2024 German study of 15 patients (8 with lupus) targeting CD19 achieved remission in all lupus patients after 112 days of B-cell depletion; a 2026 study of 24 patients saw 9/10 lupus patients in remission at 6 months. Randomized trials vs CD19 antibodies are underway, and in vivo CAR-T using lipid nanoparticles (small 2025 Chinese study, n=5) may cut cost and complexity. First mouse experiment was only in 2019.
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