Nature paper traces decades of pre-leukaemia evolution via serial blood samples
_onionesque · x · 2026-11-12
A Nature open-access paper from Caroline Watson and Jamie Blundell's lab uses annually collected blood samples — starting up to 15 years before diagnosis — plus deep duplex sequencing and evolutionary theory to quantitatively describe pre-cancerous somatic evolution preceding acute myeloid leukaemia, estimating mutation acquisition ages and fitness effects.
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