TissueMicroscopyBench: 49 evals to test AI agents on biological microscopy
kenbwork · x · 2026-11-12
Researchers introduce TissueMicroscopyBench, the first release in a new microscopy benchmark series giving agents the ability to "see" the biological world. It contains 49 evaluations built from four public imaging datasets, spanning tissues, cells, and in vitro systems. Tasks require locating structures, tracing boundaries, reasoning over 3D images, and tracking changes over time. Examples include outlining mucosa, fat, and nerves in H&E-stained colorectal cancer sections, comparing tumor compartments and PD-L1 staining in pre/post-treatment liver metastasis biopsies, and analyzing light-sheet recordings of living organoids. The authors argue agent microscopy will be an important source of scientific progress.
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