Clinical AI RCT cuts autoimmune diagnosis time from 138 to 43 days

zakkohane · x · 2026-11-09

A two-year pragmatic randomized trial in NEJM AI used a clinical AI model to flag high-risk ANA-positive patients for faster rheumatology review. Median time to autoimmune diagnosis fell to 43 vs 138 days (HR 1.9, 95% CI 1.3–2.7); among patients seen within 6 months, 23% vs 16% were diagnosed. Of 4,508 screened patients, 2,385 were randomized.

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