BILBY: New Benchmarks Test Protein Scaffold Designs for Dynamic Stability, Not Just Static Success
HFMI-PROFOUND · hf · 2026-11-09
HFMI-PROFOUND presents BILBY, new benchmarks and molecular dynamics frameworks evaluating protein scaffold-generation models on dynamic fidelity beyond static structural success. BILBY-PRO provides PROSITE-derived functional benchmarks, while BILBY-MD uses MD simulations to compare free-energy landscapes and RMSD drift between reference and generated designs, offering a stricter test of whether generative protein models produce genuinely stable structures.
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