RFD4-Proteina hits 158/188 binder success rate, crushing prior protein design methods
HannesStaerk · x · 2026-11-06
RFD4-Proteina, a latent-reasoning biomolecular design method from the Baker lab (Institute for Protein Design, UW) with NVIDIA, Oxford, Tsinghua and other collaborators, reports an experimental hit rate of 158/188 (84%) designed binders binding TrkA below 1 µM — versus 18/60 for the next-best method. The comparison chart shows PXDesign at 3/18, AlphaProteo at 12/131, and RFdiffusion at 6/95.
The author's reading group presents the paper today on Zoom. Author list includes David Baker; a major AI-for-Science advance in computational protein design.
Related event: Baker Lab and NVIDIA Release RFD4-Proteina with 84% Binder Success Rate(5 posts)→
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