SMFNet Preprint: Discrete Diffusion Model Decodes Combinatorial TF Assembly, Validated Across 15 Perturbations
anshulkundaje · x · 2026-11-06
EMBL 海德堡与斯坦福（Anshul Kundaje、Nathaniel Diamant 等）在 bioRxiv 发布 SMFNet 预印本，标题为「SMFNet reveals principles of combinatorial transcription factor assembly」。模型以离散扩散生成单分子足迹读段，还引入 PRISM 方法将单个染色质状态与转录因子 motif 关联：在 Phc3 启动子上，SMFNet 能预测 motif 缺失如何重新分布这些染色质状态，并在 15 项扰动实验中与实测结果吻合。代码已开源（kundajelab/SMFNet），揭示转录因子组合组装的组合规律。
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