Rentosertib: a 7-year quest for an aging drug worth 110 million human lifetimes
rand_longevity · x · 2026-11-02
Alex Zhavoronkov (Forever.AI) recounts his 7-year journey developing rentosertib, an anti-aging drug candidate. His framing: one extra healthy year for everyone alive equals 8.3 billion life-years, or about 110 million complete human lifetimes—returns no other intervention can match.
The core problem: after 150+ years of modern pharmacology, no drug has conclusively proven in controlled human trials to add even one year of life to an already optimized healthy person, regardless of wealth. Popular geroprotectors like metformin, rapamycin, and SGLT2 inhibitors have real biology but no conclusive human evidence. The piece also details evaluations via six different aging clocks.
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