~10x speedup for leafcutter as maintainers turn to AI to validate unreviewably large PRs

jmschreiber91 · x · 2026-10-30

A contributor to the bioinformatics tool leafcutter announced a 10x speed improvement. In the discussion, the author explains their attempt to find the best way to validate massive PRs that no human can realistically review, using AI-assisted approaches — while acknowledging there are no perfect answers. They hope the improvements prove useful to the community.

Related event: Bioinformatics Community Turns to AI Review for Massive Pull Requests(2 posts)→

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