Researcher Drops Claude 5.5 for Biology Work Over Too Many Refusals
anshulkundaje · x · 2026-10-28
Bioinformatics researcher @anshulkundaje says he stopped using Claude 5.5 for biology work because it still refuses too many requests. He adds that older Gemini models are quite bad, while GPT Astra Ultra has been excellent in his experience. A practitioner's feedback on model guardrails and usability.
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