UK AISI: under $80 of fine-tuning fully restores filtered bio capabilities in open-weight models

connoraxiotes · x · 2026-10-27

The UK AI Security Institute assessed pretraining data filtering as a safeguard for open-weight protein models. Filtering is effective and selective — it degrades targeted dual-use capabilities while leaving other performance largely intact — making it a favored justification for open release. But it isn't durable: fine-tuning on publicly available viral data with under $80 of compute fully restored the capability, even for the largest model, weakening the "filtered models are safe to open-source" argument.

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