Surprising find: Alzheimer's-linked amyloid fibrils deliver RNA to sperm for embryo translation
EricTopol · x · 2026-10-26
Eric Topol highlights a Molecular Cell study with a surprising twist: amyloid—the protein famous for its role in Alzheimer's disease—forms fibrils that bind RNA and deliver it into sperm. After fertilization, chaperones release the RNA inside the oocyte for translation in the embryo. The mechanism involves phase separation of PAP protein and RNA into fibrils, fibril internalization by sperm, and RNA release—a striking link between neurodegeneration research and reproductive biology.
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