None of the 11 grand challenges in single-cell science solved since 2020
Sauers_ · x · 2026-10-26
- Biology expert Sauers cites the 2020 Genome Biology review "Eleven grand challenges in single-cell data science" and points out that none of the 11 problems are fully solved today.
- Some are simple, like handling the fact that RNA sequencing data often doesn't detect a gene sequence; many others are plain software engineering or machine learning problems.
- The author has argued many AI people hold incorrect takes on biology, and is confident biology will not be "solved" within a lifetime — a counterpoint to optimistic AI-will-cure-everything narratives.
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