8 mixed GPUs plus 256GB DDR4 vs DGX Spark: is this MoE inference rig viable?

Ambitious_Fold_2874 · reddit · 2026-10-25

A Reddit user has assembled 4x RTX 5060 Ti 16GB + 4x RTX 3060 12GB with 256GB DDR4-3200 on a board with 128 PCIe 4.0 lanes, at cost comparable to a DGX Spark. They ask whether such a heterogeneous multi-GPU setup can run large MoE models fast and accurately, or whether it's badly suboptimal versus unified memory architectures.

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