PDB at 55: how 150,000+ experimental structures powered the AlphaFold era
BrianHie · x · 2026-10-22
The PDB-101 Molecule of the Month marks 55 years of the Protein Data Bank, tracing how AI structure prediction evolved. AlphaFold2 and RoseTTAFold are pattern-recognition systems trained on 150,000+ experimentally determined PDB structures. Three case studies — CASP 14's Orf8 prediction, flexible complex modeling, and a phage built from a synthetic genome — illustrate the field's progress since CASP began in 1994.
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