ESMFold2 API adds max accuracy mode after single-sequence precision complaints
proteinrosh · x · 2026-10-22
The ESMFold2 team acknowledged its biohub API lagged other services because it predicted in single-sequence mode only. A new max accuracy option is now available. Benchmarks show DockQ pass rates of 55 (antibody-antigen, n=172) and 77 (protein-protein, n=278) in max accuracy mode (MSA + 20 loops), beating single-sequence mode (51/71) and leading over Chai-1, Boltz-1, AlphaFold3, and Protenix.
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