ProVADA: one AI framework deimmunizes CD19 CAR binder and rescues cytosolic protease
BrianHie · x · 2026-10-21
- Xiaowei Zhao et al. present ProVADA (Protein Variant ADAPtation), a unified protein design framework combining a sequence generative model with a black-box property predictor, steering generation at test time (MADA algorithm) to confer new properties while retaining fold and function.
- Two demonstrated cases: deimmunizing a clinical CD19 CAR binder via experimentally detected HLA-I epitope depletion while preserving tumor killing, and rescuing a secreted protease to function in the cytosol.
- Significance: one framework tackles both immunogenicity removal and functional environment transfer, problems that previously required separate pipelines.
Related event: ProVADA: A Unified Framework for Adapting Proteins to Non-Native Contexts(2 posts)→
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