ETSAM adapts Segment Anything 2 to treat 3D scans as video, scoring 0.812 on membrane segmentation

bravo_abad · x · 2026-10-21

Selvaraj and Cheng adapted Segment Anything Model 2 into ETSAM for membrane segmentation in electron microscopy: successive slices of a 3D scan are treated as video frames, letting SAM2's memory carry membrane information across slices where a single slice may show the structure faintly. The method was trained on 83 experimental and 28 simulated scans with a second-stage refinement; the unmodified model failed entirely with automated prompts. Across 17 test scans ETSAM scored 0.812, beating baselines, with visual comparisons against Membrain-Seg and TARDIS.

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