Dialectic 60: Arc Institute's Patrick Hsu on biology, AI, and funding human-response datasets

MatthewMcAteer0 · x · 2026-10-19

Dialectic podcast episode 60 interviews Patrick Hsu, co-founder of Arc Institute. Expelled from college at 13, back at 15, he worked on early CRISPR breakthroughs, then founded Arc with Simon Konermann and Patrick Collison. He now holds three roles: Arc core investigator, Stanford professor, and Thrive Capital venture partner. Topics include why research is 99% failure, GLP-1s and power laws in biotech, what makes a good biologist, and Arc's bets. Related: Impetus Grants is raising $15M (>$9M raised) to fund 50 projects building datasets on how the human body responds, enabling AI to reason about aging and disease.

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