Arc Institute unveils Pythia, an interpretable AI model decoding 67 RNA-binding proteins

BoWang87 · x · 2026-10-14

Arc Institute, the genophoria lab, czbiohub, UCSF, Calico, and Vector Institute introduced Pythia, an interpretable AI model trained on a new high-resolution atlas of 67 RNA-binding proteins (RBPs). RBPs recognize RNA by both sequence and shape, and Pythia aims to decode which cue matters at each binding site — assembling an 'Avengers' team of labs including Bo Wang to tackle the grammar of RBP-RNA interactions.

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