rewrites.bio manifesto: AI rewrites of bioinformatics tools need speed and correctness
jmschreiber91 · x · 2026-10-11
A new manifesto (rewrites.bio) argues AI coding assistants now let domain experts rewrite established scientific software in days instead of years — and the bioinformatics community needs norms to handle the coming rewrite wave. Key case: RustQC cuts 10GB BAM processing from 15:34 to 0:15 (63× faster), saving 1.5M CPU-hours and 150t CO₂e per 100k samples/year. Core principles: rewrites must match original outputs exactly, credit original authors, and avoid fragmenting the ecosystem — cheap code is not the same as correct code.
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