Surprise Find: Deleting Distal Silencer s1 Boosts PPIF Expression 30%
anshulkundaje · x · 2026-10-10
The most surprising finding of the study: a distal silencer of PPIF, dubbed s1, where all deletions led to a 30% increase in gene expression.
How does this element regulate a gene 60 kb away, and by what mechanism? The authors tested five plausible models one by one.
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