De novo glycoprotein design: glycans become a designable parameter in new preprint
DaveJuergens · x · 2026-10-10
- A preprint from the IPD King Lab reports that glycosylation, long outside the reach of biomolecular design, can now be controlled via all-atom methods to dictate the glycan types displayed on de novo proteins.
- The team built multiple structurally-encoded oligomannose-type glycoproteins, establishing glycans as a designable parameter—programming protein function through post-translational modification rather than the 20 amino acids alone.
- rkrishna3 notes most protein design ignores post-translational modifications like glycosylation, which are essential to function in biology.
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