No natural enzyme fits piperidines: de novo design fills the gap, ensemble filtering hailed
AllThingsApx · x · 2026-10-06
A protein design study compared natural sequence mining vs de novo design head-to-head on the same target reaction for the first time. Piperidine rings are common in medicines; screening 188 natural enzymes found none with high specificity, while de novo design could create novel-to-nature starting points. Commenters highlight the ensemble-based filtering approach as promising for other protein design subfields.
More from Research
- UCLA PhD's LLM agents produce 126K-line Lean 4 proof of MIP* = RE core theorem in 63 days — siyan_zhao · 2026-10-06
- UniReps 4th edition heads to Paris on Dec 12, 2026, with submissions extended to Oct 10 — ClementineDomi6 · 2026-10-06
- AI-generated key-value stores beat general-purpose DBs via specialized architecture — CShorten30 · 2026-10-06
- Real2sim's last mile for robotics: verification pipeline for physics and affordance — chris_j_paxton · 2026-10-06
- LenVM lands COLM 2026 Spotlight: value model predicts remaining generation length for efficient reasoning — xwang_lk · 2026-10-06
- I tested 20+ ways to make a cheap coding model act like an expensive one — KangarooAnxious9394 · 2026-10-06