Evo-Φ36 cryo-EM structure featured in PDB's 55th anniversary Molecule of the Month
BrianHie · x · 2026-10-01
The cryo-EM structure of Evo-Φ36, a phage built from a synthetic genome, is featured in the Protein Data Bank's 55th anniversary "Molecule of the Month" article.
The article traces AI-driven protein structure prediction: systems like AlphaFold2 learned amino acid sequence-to-fold patterns from over 150,000 experimentally determined PDB structures, progressing from AlphaFold2's successful CASP14 prediction of SARS-CoV-2 Orf8, to modeling flexible molecular complexes, to the structure of a synthetic-genome phage.
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